Westbound Interstate 10 was closed near State Route 51 on Sunday afternoon because of a crash that killed two people.
Two adults — a man and a woman — were declared dead on the scene.
Traffic will be detoured to State Route 51 northbound.
Four lanes of I-10 remain closed while two right lanes going westbound have opened. Two eastbound lanes are also closed because of the accident.
Drivers are urged to use alternate routes.
Those traveling westbound on Loop 202 and southbound on State Route 51 will not be able to access I-10 westbound because of the crash, according to the Arizona Department of Transportation.